Plenary Paper MYELOID NEOPLASIA Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
نویسندگان
چکیده
Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany; Department of Internal Medicine III, Ulm University, Ulm, Germany; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Haematology, Cambridge Institute of Medical Research, and Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom; Department of Hematology and Oncology, Eberhard Karls University, Tübingen, Germany; Department of Hematology and Oncology, Otto von Guericke University, Magdeburg, Germany; Clinical Cooperation Unit Molecular Hematology and Oncology, German Cancer Research Center, and Department of Internal Medicine V, Ruprecht Karls University, Heidelberg, Germany; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA; Leukemia Center, Human Oncology and Pathogenesis Program and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY; Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, PA; and Heidelberg Institute for Stem Cell Technology and Experimental Medicine and Division of Stem Cells and Cancer, Experimental Hematology Group, German Cancer Research Center, Heidelberg, Germany
منابع مشابه
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in hematopoietic progenitors and give rise to an aggressive subtype of acute myeloid leukemia (AML). Insights into MLL fusion-mediated leukemogenesis have not yet translated into better therapies because MLL is difficult to target directly, and the identity of the genes ...
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